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Author Spotlight: Investigating Wound Healing in Mice Models of Oronasal Fistulas
Published on: September 8, 2023
CLOSED HEALING OF THE PALATE MUCOSA: INDEX ASSESSMENT AND CLINICAL SIGNIFICANCE
Y Bakaev1, M Makarova1, Z Khabadze1
1Peoples' Friendship University of Russia named after Patrice Lumumba, Moscow, Russian Federation.
Introduction:
Assessment of wound healing in the oral cavity is essential for clinical decision-making after soft tissue surgical procedures. In palatal donor sites managed with wound coverings, direct visual evaluation of epithelialization is limited, creating the need for a dedicated and standardized closed-healing assessment tool.
Objective:
To describe and clinically validate the Closed Palatal Mucosal Healing Index (CPMHI) for the assessment of palatal donor site healing under conditions of wound coverage.
Materials And Methods:
A total of 192 patients undergoing surgical treatment involving palatal donor tissue harvesting were initially enrolled as part of a broader clinical dataset. For the purposes of CPMHI validation, the present study specifically analyzed two groups (Groups 3 and 4; n=64) in which the donor site was managed using a collagen sponge fixed with sutures and covered with either ethyl or butyl cyanoacrylate adhesive. Clinical evaluation of healing was performed on postoperative days 7 and 14 using the CPMHI. Statistical analysis was conducted to compare healing dynamics between the two groups.
Results:
On postoperative day 7, the majority of patients in both groups demonstrated satisfactory healing (CPMHI score 3), with no statistically significant differences between Group 3 and Group 4 (p>0.05). By day 14, most patients achieved good or excellent healing (CPMHI scores 4-5), indicating effective integration of the wound covering and minimal inflammatory response. No statistically significant intergroup differences were detected at either time point (p>0.05).
Conclusion:
The Closed Palatal Mucosal Healing Index demonstrated clinical applicability, objectivity, and convenience for assessing palatal wound healing in the presence of wound coverings. CPMHI represents a reliable tool for standardized evaluation of closed healing dynamics in clinical practice and research settings.
