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INFLUENCE OF PROFICIENCY OF SYNTHETIC FOLIC ACID ON THE NEUROLOGICAL SYMPTOMS OF RATS.

D Kachanov1, A Karabanova1, M Knyazeva1

  • 1North-Western Medical University named after I.I. Mechnikov, Saint-Petersburg, Russia.

Georgian Medical News
|July 31, 2023
PubMed
Summary
This summary is machine-generated.

High folic acid intake during pregnancy may increase seizure risk in offspring. This study in Wistar rats suggests excess folate impacts neural development and synaptic transmission, potentially leading to neuropathologies.

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Nutritional Science

Background:

  • Folic acid is essential for vital biological processes, including methylation and nucleotide synthesis.
  • Maternal folic acid supplementation reduces risks of fetal neural tube defects but high doses may have adverse effects.
  • Folic acid's excitatory effect on synaptic transmission is linked to its L-glutamate content.

Purpose of the Study:

  • To investigate the correlation between increased folic acid dosage during gestation and offspring neuropathologies.
  • To assess the impact of prenatal folate excess on seizure thresholds in a rat model.
  • To explore potential alterations in synaptic density and neurodevelopment due to high folic acid intake.

Main Methods:

  • Wistar rats were administered varying dosages of folic acid (1 mg/kg/diet and 5 mg/kg/diet) during gestation and pre-gravidar preparation.
  • Seizure thresholds were measured by assessing clonus time in the offspring.
  • Control groups received standard diets without excess folic acid.

Main Results:

  • Offspring exposed to high folic acid doses exhibited significantly reduced average clonus times (797.3s and 439.7s) compared to controls (1779.6s).
  • A dose-dependent decrease in seizure threshold was observed with increasing folic acid intake.
  • Results indicate a potential link between excess synthetic folic acid and altered synaptic density.

Conclusions:

  • Excessive folic acid during gestation may negatively impact central nervous system development in offspring.
  • High folate levels could affect neurogenesis and neural network formation, potentially increasing seizure susceptibility.
  • Further research is needed to understand the long-term neurological consequences of prenatal folate excess.