SERUM LIPOCALIN-2, AND FETUIN-A LEVELS IN PATIENTS WITH ALZHEIMER'S DISEASE

Alzheimer's disease is a neurodegenerative disease leading to a progressive and irreversible loss of mental functions. It is characterized by 3 stages according to the evolution and the severity of the symptoms. The authors of the present study aimed to investigate the levels of serum lipocalin-2, fetuin-A, and TNF-α in patients with Alzheimer's disease. 56 patients with Alzheimer's disease (the first group), and another 25 healthy volunteers (control group) were enrolled in this cross-sectional study. The serum levels of lipocalin-2, fetuin-A, and Tumor necrosis factor (TNF-α) were determined with the use of the ELISA method. There was a significant elevation in serum lipocalin-2, and TNF-α levels in the AD group (88.68±32.1) and(42.28±5.05) respectively, compared to the control group (63±28.5), and (35.19±5.07) respectively, [p<0.001]. A significant increase in serum concentration of lipocalin, TNFa with a reduction of fetuin-A could be considered an important phenomenon used for follow-up or prognosis and diagnosis of Alzheimer's disease.