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SERUM LIPOCALIN-2, AND FETUIN-A LEVELS IN PATIENTS WITH ALZHEIMER'S DISEASE
Georgian Medical News
|June 24, 2023
Summary
Serum lipocalin-2 and Tumor Necrosis Factor-alpha (TNF-α) levels are elevated in Alzheimer's disease patients. These biomarkers, along with reduced fetuin-A, may aid in diagnosis and prognosis.
Area of Science:
- Neuroscience
- Biochemistry
- Medical Diagnostics
Background:
- Alzheimer's disease (AD) is a progressive neurodegenerative disorder causing irreversible cognitive decline.
- AD is typically staged based on symptom severity and progression.
- Identifying reliable biomarkers for AD diagnosis and prognosis is crucial.
Purpose of the Study:
- To investigate serum levels of lipocalin-2, fetuin-A, and Tumor Necrosis Factor-alpha (TNF-α) in patients with Alzheimer's disease.
- To assess the potential of these proteins as biomarkers for AD.
Main Methods:
- A cross-sectional study involving 56 Alzheimer's disease patients and 25 healthy controls.
- Serum concentrations of lipocalin-2, fetuin-A, and TNF-α were quantified using the Enzyme-Linked Immunosorbent Assay (ELISA) method.
Main Results:
- Significantly elevated serum levels of lipocalin-2 (p<0.001) and TNF-α (p<0.001) were observed in the AD group compared to controls.
- A trend towards reduced fetuin-A levels was noted in AD patients, though not explicitly stated as significant in the provided text.
Conclusions:
- Increased serum lipocalin-2 and TNF-α, coupled with decreased fetuin-A, represent a significant phenomenon in Alzheimer's disease.
- These altered protein levels show potential as important indicators for monitoring, prognosis, and diagnosis of Alzheimer's disease.
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