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STUDY OF THE HEMOMICROCIRCULATORY CHANNEL IN PATIENTS WITH DIABETES AND THREATENING ISCHEMIA OF THE LOWER LIMB

S Didenko1, V Subbotin1, Yu Hupalo2

  • 11Clinical Hospital «Feofaniya» of State Directorate for Affairs, Kyiv, Ukraine.

Georgian Medical News
|June 24, 2023
PubMed

Insights

This study investigated the hem microcirculatory channel in patients with chronic critical lower extremity ischemia and diabetes. A new method was developed to calculate diabetic microangiopathy, revealing correlations with thrombosis risk.

Area of Science:

  • Vascular Biology
  • Diabetology
  • Microcirculation Research

Background:

  • Chronic critical lower extremity ischemia (CHLIC) in diabetes mellitus (DM) significantly impacts patient outcomes.
  • Understanding microcirculatory changes is crucial for managing diabetic complications.

Purpose of the Study:

  • To investigate the hem microcirculatory channel (HCMC) in patients with CHLIC and type 2 DM.
  • To develop a quantitative indicator for diabetic microangiopathy (PSDMAP).
  • To explore the relationship between microangiopathy and thrombosis risk post-revascularization.

Main Methods:

  • Histological and immunohistochemical analysis of skin and muscle samples.
  • Measurement of blood vessel diameters and capillary density.
  • Development and application of the PSDMAP calculation method.

Main Results:

  • Identified characteristic morphometric changes in the HCMC of diabetic patients with CHLIC.
  • Successfully developed and validated the PSDMAP calculation method.
  • Established a correlation between diabetic microangiopathy type and post-hybrid arterial reconstruction thrombosis probability.

Conclusions:

  • Diabetic microangiopathy significantly alters HCMC in CHLIC.
  • PSDMAP provides a valuable metric for assessing microvascular damage.
  • The findings support an algorithm for postoperative patient management to mitigate thrombosis risk.

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