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THE STUDY OF LIVER AND KIDNEY FUNCTION WITHIN COVID-19 PATIENTS
I Murvanidze1, O Tsetskhladze1, E Saralidze1
11Faculty of Natural Sciences and Health Care, Batumi Shota Rustaveli State University, Georgia.
Insights
This study on coronavirus disease 2019 (COVID-19) found elevated liver enzymes (ALT, AST) and creatinine in patients. High creatinine levels may indicate increased risk for severe COVID-19 outcomes.
Area of Science:
- Medical research
- Clinical pathology
Background:
- Coronavirus disease 2019 (COVID-19) affects multiple organs, including the liver and kidneys.
- Understanding clinical characteristics in severe COVID-19 is crucial.
Purpose of the Study:
- To evaluate clinical characteristics of COVID-19 patients with abnormal liver and kidney function tests.
- To assess differences between recovered and deceased patients.
Main Methods:
- Analyzed 289 COVID-19 patients using PCR for diagnosis.
- Measured ALT, AST, and creatinine levels in blood plasma.
- Utilized Prestige 24i analyzer and GraphPad Prism software for analysis.
Main Results:
- Elevated AST and ALT levels were observed compared to reference values.
- Creatinine levels were significantly higher in both men and women.
- A notable difference in creatinine levels was found between recovered and deceased patients.
Conclusions:
- Abnormal liver function tests (ALT, AST) are associated with COVID-19.
- Elevated creatinine levels, particularly in men, may be a risk factor for COVID-19 severity.
Abstract:
Goal -the existing data on the coronavirus disease 2019 (COVID-19) revealed the impact of the disease on different organs such as the liver, the heart, the kidneys, etc. In our study, we evaluated the clinical characteristics of COVID-19 in patients with abnormal liver and kidney test results in recovered and dead patients. The number of the covid-19 patients was - 289. The gold standard method of polymerase chain reaction (PCR) was used to detect the infection of Covid-19. Blood plasma was used as research material. For The Determination of ALT, AST, and Creatinine, the Analyzer was the Prestige 24i - optimized, modified method according to the International Federation of Clinical Chemistry (IFCC), without pyridoxal phosphate; For the statistical analysis were used the Graphed Prism (Version 8.0). Studies have revealed an increase in AST and ALT compared with the reference value. A small difference was also found between those who died and those who recovered; A change in creatinine levels was also found. Men have a high level of Creatinine (~4.28 times) compared to the reference level, and in women, the level of Creatinine is ~2.18 times higher than the reference level. We have thought that according to our results, the high creatinine levels may have some risk impact for the severity of COVID-19 disease.
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