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Related Concept Videos

Lymphatic Vessels and Lymph Transport01:16

Lymphatic Vessels and Lymph Transport

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Lymphatic vessels, known as lymphatics, are crucial in transporting lymph from peripheral tissues to our venous system. This process begins with lymph entering through tiny capillaries that branch through tissues. These capillaries have unique features such as larger diameters, thinner walls, and a distinctive one-way valve system formed by overlapping endothelial cells.
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Blood and Nerve Supply to the Kidney01:18

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The kidneys are vital organs responsible for filtering and cleaning blood, removing waste products, and regulating electrolyte levels. To perform these essential functions, they require a constant and robust blood supply.
Bloody Supply to the Kidneys:
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Kidney Structure

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The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.
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Detailed Structure and Function of Lymph Nodes01:23

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Lymph nodes are bean-shaped structures that cluster along the lymphatic vessels in the inguinal, axillary, and cervical regions. Each node is divided into compartments by a capsule that extends trabeculae inward.
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Development of the Lymphatic System01:15

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The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
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Physiology of the Genitourinary System I: Renal Blood Flow and Glomerular Filtration01:29

Physiology of the Genitourinary System I: Renal Blood Flow and Glomerular Filtration

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The kidneys are vital organs responsible for regulating blood filtration, waste excretion, and fluid balance, all of which are crucial for maintaining homeostasis. Renal physiology examines renal blood flow, glomerular filtration, and urine formation, ensuring the body’s internal environment remains stable.Renal Blood FlowThe kidneys receive about 20-25% of the cardiac output, typically around 1200 mL of blood per minute in an average adult. Blood flows into the kidneys through the renal...
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Blocking Lymph Flow by Suturing Afferent Lymphatic Vessels in Mice
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Kidney Lymphatics.

Peter S Russell1,2, Max Itkin3, John A Windsor2

  • 1Applied Surgery and Metabolism Laboratory, School of Biological Sciences, Faculty of Science, University of Auckland, Auckland, New Zealand.

Comprehensive Physiology
|June 26, 2023
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Summary
This summary is machine-generated.

Kidney lymphatics are crucial for kidney health, regulating fluid and immune balance. Recent discoveries highlight their role in kidney diseases, paving the way for new lymphatic-targeted therapies.

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Area of Science:

  • Physiology
  • Lymphatic Biology
  • Renal Science

Background:

  • The role of kidney lymphatics in renal function and disease is increasingly recognized.
  • Kidney lymphatics, originating in the cortex and exiting at the hilum, are vital for draining interstitial fluid, macromolecules, and cells.
  • Maintaining kidney fluid and immune homeostasis relies on lymphatic function.

Approach:

  • This article comprehensively reviews established and recent research on kidney lymphatics.
  • Utilizes lymphatic molecular markers to enhance understanding of kidney lymphatic development, anatomy, and pathophysiology.
  • Integrates findings from diverse research disciplines.

Key Points:

  • Diverse embryological origins of kidney lymphatics have been identified.
  • The ascending vasa recta exhibit a hybrid lymphatic-venous nature.
  • Lymphangiogenesis significantly impacts kidney diseases, including acute kidney injury and renal fibrosis.

Conclusions:

  • Recent advances in understanding kidney lymphatics offer opportunities for novel therapeutic strategies.
  • Targeting kidney lymphatics presents a promising new era for treating kidney diseases.
  • Interdisciplinary collaboration is essential to translate lymphatic research into clinical applications.