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Zfp362 potentiates murine colonic inflammation by constraining Treg cell function rather than promoting Th17 cell

Susanne Herppich1, Lisa Hoenicke1, Fabian Kern2,3

  • 1Department Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany.

European Journal of Immunology
|June 27, 2023
PubMed
Summary

Zinc finger protein 362 (Zfp362) constrains regulatory T cell (Treg) function, impacting colonic inflammation. Its absence increases Treg cells, reducing inflammation severity, rather than affecting T helper 17 (Th17) cell differentiation.

Keywords:
Intestinal ImmunityMucosal inflammationTh17Treg cellZfp362

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