Related Experiment Video
Updated: Jul 25, 2025
06:40
Biofunctionalization of Magnetic Nanomaterials
Published on: July 16, 2020
2.7K
The Developments of Surface-Functionalized Selenium Nanoparticles and Their Applications in Brain Diseases Therapy
1Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China.
Biomimetics (Basel, Switzerland)
|June 27, 2023
Summary
Nanoscale selenium particles (SeNPs) offer improved bioavailability and bioactivity for treating diseases like cancer and diabetes. Surface functionalization enhances SeNP stability and therapeutic potential, particularly for brain diseases.
Area of Science:
- Biomedical Engineering
- Materials Science
- Nanotechnology
Background:
- Selenium (Se) compounds are used in supplements but bulk Se has low bioavailability and high toxicity.
- Nanoscale selenium particles (SeNPs) show promise in treating oxidative stress-related diseases due to enhanced bioavailability and bioactivity.
- Pure SeNPs face stability issues, limiting their therapeutic applications.
Purpose of the Study:
- To review synthesis methods for SeNPs.
- To explore surface functionalization strategies for improving SeNP stability and biological activity.
- To highlight the application of functionalized SeNPs in treating brain diseases.
Main Methods:
- Review of literature on SeNP synthesis.
- Analysis of surface functionalization techniques for SeNPs.
- Examination of SeNP applications in preclinical and clinical studies for brain diseases.
Main Results:
- Various SeNP morphologies (nanowires, nanorods, nanotubes) can be synthesized.
- Surface functionalization significantly improves SeNP stability and therapeutic efficacy.
- Functionalized SeNPs demonstrate potential in managing neurodegenerative and other brain disorders.
Conclusions:
- Nanoscale selenium particles offer a promising platform for disease therapy.
- Surface functionalization is crucial for overcoming SeNP limitations and enhancing their biomedical utility.
- Functionalized SeNPs represent a novel therapeutic strategy for brain diseases.
