Related Experiment Video
Updated: Jul 25, 2025
MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor
Published on: December 13, 2017
Fluoroquinolone-Associated Movement Disorder: A Literature Review
Jamir Pitton Rissardo1, Ana Letícia Fornari Caprara1
1Medicine Department, Federal University of Santa Maria, Santa Maria 97105-900, Brazil.
Background:
Fluoroquinolones (FQNs) are related to several central nervous system side effects. This review aims to evaluate the clinical-epidemiological profile, pathophysiological mechanisms, and management of FQNs-associated movement disorders (MDs).
Methods:
Two reviewers identified and assessed relevant reports in six databases without language restriction between 1988 and 2022.
Results:
A total of 45 reports containing 51 cases who developed MDs secondary to FQNs were reported. The MDs included 25 myoclonus, 13 dyskinesias, 7 dystonias, 2 cerebellar syndromes, 1 ataxia, 1 tic, and 2 undefined cases. The FQNs reported were ciprofloxacin, ofloxacin, gatifloxacin, moxifloxacin, levofloxacin, gemifloxacin, and pefloxacin. The mean and median age were 64.54 (SD: 15.45) and 67 years (range: 25-87 years). The predominant sex was male (54.16%). The mean and median time of MD onset were 6.02 (SD: 10.87) and 3 days (range: 1-68 days). The mean and median recovery time after MD treatment was 5.71 (SD: 9.01) and 3 days (range: 1-56 days). A complete recovery was achieved within one week of drug withdrawal in 80.95% of the patients. Overall, 95.83% of the individuals fully recovered after management.
Conclusions:
Future cases need to describe the long-term follow-up of the individuals. Additionally, FQN-induced myoclonus should include electrodiagnostic studies.
Insights
Fluoroquinolones (FQNs) can cause movement disorders (MDs). Most patients fully recovered after drug withdrawal and management, but long-term follow-up is needed for FQN-induced MDs.
Area of Science:
- Neurology
- Pharmacology
- Clinical Medicine
Background:
- Fluoroquinolones (FQNs) are associated with central nervous system side effects.
- Movement disorders (MDs) are a known, albeit uncommon, adverse effect of FQNs.
Purpose of the Study:
- To review the clinical-epidemiological profile of FQN-associated movement disorders.
- To explore the pathophysiological mechanisms and management strategies for FQN-induced MDs.
Main Methods:
- Systematic review of reports from six databases (1988-2022).
- Inclusion of 45 reports detailing 51 cases of FQN-associated MDs.
- Analysis of patient demographics, FQN types, MD types, onset, and recovery.
Main Results:
- The most common MDs were myoclonus (25 cases) and dyskinesias (13 cases).
- Patients were predominantly male (54.16%), with a mean age of 67 years.
- Over 95% of individuals fully recovered after management, with 80.95% recovering within a week of drug withdrawal.
Conclusions:
- FQNs can induce a range of movement disorders, with myoclonus being the most frequent.
- Prompt drug withdrawal and management lead to high recovery rates.
- Further research should focus on long-term follow-up and incorporating electrodiagnostic studies for FQN-induced myoclonus.
More Related Videos
05:52Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
Published on: November 21, 2013
10:41Implantation of Osmotic Pumps and Induction of Stress to Establish a Symptomatic, Pharmacological Mouse Model for DYT/PARK-ATP1A3 Dystonia
Published on: September 12, 2020
Related Concept Videos
01:18Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents
01:28Disorders of the Skeletal Muscle
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
01:15Parkinson's Disease: Overview