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Drug Delivery Systems for Personal Healthcare by Smart Wearable Patch System
Bikram Khadka1, Byeongmoon Lee2, Ki-Taek Kim1,3
1Department of Biomedicine, Health & Life Convergence Sciences (BK21 Four), Biomedical and Healthcare Research Institute (BHRI), Mokpo National University, Muan-gun 58554, Jeonnam, Republic of Korea.
Abstract:
Smart wearable patch systems that combine biosensing and therapeutic components have emerged as promising approaches for personalized healthcare and therapeutic platforms that enable self-administered, noninvasive, user-friendly, and long-acting smart drug delivery. Sensing components can continuously monitor physiological and biochemical parameters, and the monitoring signals can be transferred to various stimuli using actuators. In therapeutic components, stimuli-responsive carrier-based drug delivery systems (DDSs) provide on-demand drug delivery in a closed-loop manner. This review provides an overview of the recent advances in smart wearable patch systems, focusing on sensing components, stimuli, and therapeutic components. Additionally, this review highlights the potential of fully integrated smart wearable patch systems for personalized medicine. Furthermore, challenges associated with the clinical applications of this system and future perspectives are discussed, including issues related to drug loading and reloading, biocompatibility, accuracy of sensing and drug delivery, and largescale fabrication.
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