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ALM Therapy Promotes Functional and Histologic Regeneration of Traumatized Peripheral Skeletal Muscle.

Nina Sarah Hoeger1, Thomas Mittlmeier1, Brigitte Vollmar2

  • 1Department of Trauma and Reconstructive Surgery, University of Rostock, 18057 Rostock, Germany.

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|June 28, 2023
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Summary

Adenosine, lidocaine, and Mg2+ (ALM) solution significantly enhanced skeletal muscle repair after trauma. ALM improved biomechanical function and promoted cell proliferation while reducing cell death.

Keywords:
ALM solutionapoptosismuscle contraction forcemuscle crush injurymuscle regenerationproliferation

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Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Skeletal Muscle Physiology

Background:

  • Skeletal muscle trauma is a frequent and severe injury.
  • Adenosine, lidocaine, and Mg2+ (ALM) solution is known to improve tissue perfusion and coagulopathy.

Purpose of the Study:

  • To evaluate the efficacy of ALM solution in promoting skeletal muscle regeneration after trauma.
  • To assess the impact of ALM on biomechanical properties, cell proliferation, and apoptosis.

Main Methods:

  • Male Wistar rats with standardized soleus muscle trauma were treated with either saline or ALM solution.
  • Biomechanical testing (incomplete tetanic force and tetany) and immunohistochemistry (BrdU, Ki67, TUNEL) were performed at multiple time points post-trauma.

Main Results:

  • ALM treatment significantly increased incomplete tetanic force and tetany on days 4 and 7.
  • Histological analysis revealed increased cell proliferation (BrdU, Ki67) and decreased apoptosis (TUNEL) in ALM-treated rats.
  • ALM demonstrated superiority in restoring biomechanical function and promoting regenerative processes.

Conclusions:

  • ALM solution significantly accelerates skeletal muscle regeneration following trauma.
  • ALM enhances biomechanical recovery, promotes cell proliferation, and reduces apoptosis in injured muscle tissue.