Design of Tailor-Made Biopolymer-Based Capsules for Biological Application by Combining Porous Particles and...

Area of Science:

• Biomaterials Science
• Nanotechnology
• Polymer Chemistry

Background:

• Biopolymer particles offer tunable characteristics like size and mechanical properties, influencing biodistribution and bioavailability.
• Core-shell nanoparticles, particularly biopolymer-based capsules, are versatile platforms for drug delivery.
• Polysaccharide-based capsules are a key focus due to their biological compatibility and design flexibility.

Purpose of the Study:

• To review the design and fabrication of polysaccharide-based biopolyelectrolyte capsules.
• To detail the methods for creating and characterizing these capsules using sacrificial templates.
• To showcase the biomedical applications and benefits of polysaccharide capsules in drug delivery.

Main Methods:

• Fabrication of sacrificial porous templates.
• Multilayer coating with polysaccharides via the layer-by-layer technique.
• Removal of the sacrificial template to yield hollow capsules.
• Capsule characterization and evaluation for biomedical applications.

Main Results:

• Successful fabrication of polysaccharide-based capsules with controlled properties.
• Demonstration of layer-by-layer assembly on porous templates for capsule formation.
• Evidence of capsule utility in various biomedical applications, particularly drug delivery.
• Highlighting the advantages of polysaccharide capsules for biological systems.

Conclusions:

• Polysaccharide-based capsules are effectively designed using layer-by-layer assembly on sacrificial templates.
• These capsules present significant potential as drug delivery vehicles due to their tunable properties.
• The review underscores the benefits of employing polysaccharide capsules in biological and biomedical fields.