Related Experiment Video
Updated: Jul 25, 2025
09:41
Intrastriatal Injection of Autologous Blood or Clostridial Collagenase as Murine Models of Intracerebral Hemorrhage
Published on: July 3, 2014
14.9K
Long non-coding RNAs in intracerebral hemorrhage
Chenyu Zhang1,2, Ying Zhang1, Qi Wang1
1Department of Pharmacy, West China Hospital, Sichuan University, Chengdu, China.
Frontiers in Molecular Neuroscience
|June 28, 2023
Summary
This review summarizes recent advances in long non-coding RNAs (lncRNAs) and their role in intracerebral hemorrhage (ICH). It highlights lncRNAs as potential therapeutic targets for treating this severe stroke subtype.
Area of Science:
- Neuroscience
- Molecular Biology
- Genetics
Background:
- Intracerebral hemorrhage (ICH) is a severe stroke subtype causing significant disability and mortality.
- Current pharmacological treatments for ICH have uncertain effectiveness.
- Long non-coding RNAs (lncRNAs) are emerging as critical regulators in various biological processes.
Purpose of the Study:
- To review and summarize recent research on the role of lncRNAs in intracerebral hemorrhage (ICH).
- To highlight the regulatory functions of lncRNAs in the pathological mechanisms of ICH.
- To explore the potential of lncRNAs as therapeutic targets for ICH treatment.
Main Methods:
- Literature review of recent studies on lncRNAs and ICH.
- Analysis of identified and profiled lncRNAs.
- Synthesis of evidence on lncRNA regulation in ICH pathogenesis.
Main Results:
- Emerging evidence implicates lncRNAs in the development and progression of ICH.
- Specific lncRNAs have been identified and profiled in relation to ICH.
- Regulation of lncRNAs shows potential for therapeutic intervention in ICH.
Conclusions:
- lncRNAs play a critical role in intracerebral hemorrhage.
- Targeting lncRNAs offers a promising avenue for novel ICH therapies.
- Further research is needed to fully elucidate lncRNA functions and therapeutic potential in ICH.
