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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Assembly of Signaling Complexes01:30

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Multiprotein signaling complexes are formed in a dynamic process involving protein-protein interactions at the cytoplasmic domain of transmembrane receptors or enzymatic and non-enzymatic proteins associated with the receptor. These complexes ensure the activation and propagation of intracellular signals that regulate cell functions.
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Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
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Cytoskeletal filaments are polymeric forms of smaller protein subunits. However, individual cytoskeletal filaments may easily disassemble or associate with other similar filaments to form rigid structures. Microfilaments, made of actin monomers, rely on actin-binding proteins to form bundles and create networks of individual actin filaments. Microtubules rely on microtubule-associated proteins (MAPs) to form sturdy cylindrical structures. However, the proteins involved in forming complex...
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Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
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A Tripeptide-Stabilized Nanoemulsion of Oleic Acid
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Peptide Assemblies for Cancer Therapy.

Yuchen Qiao1, Bing Xu1

  • 1Department of Chemistry, Brandeis University, 415 South Street, Waltham, MA 02454, USA.

Chemmedchem
|June 28, 2023
PubMed
Summary
This summary is machine-generated.

Peptide self-assembly creates supramolecular medicine for cancer therapy. Recent advances focus on combining peptide assemblies with drugs and using enzyme-controlled transformations to inhibit cancer cells and tumors.

Keywords:
cancer therapyenzymepeptideself-assemblysupramolecular medicine

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Oncology

Background:

  • Peptide self-assembly forms supramolecular structures with diverse applications.
  • Initial research focused on tissue engineering and regenerative medicine.
  • Emerging applications highlight peptide assemblies as novel cancer therapeutics.

Purpose of the Study:

  • To review recent progress in applying peptide assemblies for cancer therapy.
  • To emphasize advancements in the last five years.
  • To explore future therapeutic potential.

Main Methods:

  • Review of seminal works in peptide self-assembly.
  • Analysis of studies combining peptide assemblies with anticancer drugs.
  • Highlighting enzyme-controlled transformations and shapeshifting strategies.

Main Results:

  • Peptide assemblies show promise as supramolecular medicine for cancer.
  • Combination therapies enhance drug delivery and efficacy.
  • Enzyme-responsive peptide assemblies demonstrate cancer cell and tumor inhibition.

Conclusions:

  • Peptide assemblies represent a promising frontier in cancer therapy.
  • Further research into drug conjugation and responsive systems is warranted.
  • This field offers potential for developing innovative cancer therapeutics.