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Updated: Jul 25, 2025

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells
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Targeting cGAS/STING signaling-mediated myeloid immune cell dysfunction in TIME

Vijay Kumar1, Caitlin Bauer2, John H Stewart3,4,5

  • 1Department of Interdisciplinary Oncology, Stanley S. Scott Cancer Center, School of Medicine, Louisiana State University Health Science Center (LSUHSC), 1700 Tulane Avenue, New Orleans, LA, 70012, USA. vkuma2@lsuhsc.edu.

Journal of Biomedical Science
|June 28, 2023
PubMed

Insights

Myeloid immune cells (MICs) detect cellular changes via pattern recognition receptors (PRRs). This review explores how cGAS/STING signaling in MICs impacts the tumor microenvironment (TME) and offers immunotherapy strategies.

Area of Science:

  • Immunology
  • Oncology
  • Cellular Biology

Background:

  • Myeloid immune cells (MICs) are crucial first responders to pathogens and cellular homeostasis disruptions.
  • Cancer involves altered homeostasis, with MICs recognizing these changes through pattern recognition receptors (PRRs).
  • Cytosolic PRRs, like cGAS/STING, detect double-stranded DNA (dsDNA), with longer dsDNA triggering stronger signaling.

Purpose of the Study:

  • To discuss tumor-supportive alterations in MICs within the tumor microenvironment (TME).
  • To emphasize the role of cGAS/STING signaling in modifying the tumor immune microenvironment (TIME).
  • To explore the potential of modulating MIC-specific cGAS/STING signaling for cancer immunotherapy.

Main Methods:

  • Review of existing literature on MICs, PRRs, and cGAS/STING signaling in cancer.
  • Analysis of how cGAS/STING activation influences the TME.
  • Discussion of therapeutic strategies targeting cGAS/STING in MICs.

Main Results:

  • cGAS/STING signaling in MICs can promote tumor growth by altering the TME.
  • The strength of cGAS/STING activation correlates with type 1 interferon and cytokine production.
  • Dysregulation of cGAS/STING in MICs contributes to tumor progression.

Conclusions:

  • Modulating MIC-specific cGAS/STING signaling is a promising avenue for cancer immunotherapy.
  • Targeting cGAS/STING can reprogram the TIME to enhance anti-tumor immunity.
  • Understanding cGAS/STING pathways in MICs is critical for developing novel cancer treatments.
Keywords:
CancerDCsMDSCsMICMacrophagesSTINGTIMETMEcGAS

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