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Exosomes released from macrophages infected with Talaromyces marneffei activate the innate immune responses and

Guangquan Ji1,2, Shan Feng1,2, Hong Ren3,4

  • 1Department of Technology, Lianyungang Clinical College of Nanjing Medical University, Lianyungang, China.

Immunity, Inflammation and Disease
|June 29, 2023
PubMed
Summary
This summary is machine-generated.

Exosomes from Talaromyces marneffei-infected macrophages stimulate innate immunity. These exosomes modulate inflammation and control fungal replication by activating ERK1/2 and autophagy pathways.

Keywords:
ERK1/2Talaromyces marneffeiexosomesmacrophages

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Area of Science:

  • Cell Biology
  • Immunology
  • Mycology

Background:

  • Exosomes are implicated in disease pathogenesis and treatment.
  • Talaromyces marneffei (T. marneffei) infection affects macrophages.
  • The role of exosomes in T. marneffei infection is not well understood.

Purpose of the Study:

  • To investigate the influence of exosomes from T. marneffei-infected macrophages on human macrophages.
  • To determine the role of these exosomes in T. marneffei infection pathogenesis.

Main Methods:

  • Exosomes were isolated from T. marneffei-infected macrophages and characterized.
  • Effects on IL-10 and TNF-α secretion were measured.
  • Activation of ERK1/2 and autophagy was assessed.

Main Results:

  • Exosomes promoted ERK1/2 and autophagy activation, and IL-10/TNF-α secretion in human macrophages.
  • Exosomes reduced T. marneffei multiplication in infected macrophages.
  • Exosomes from infected macrophages stimulated innate immune responses.

Conclusions:

  • Exosomes from T. marneffei-infected macrophages modulate the immune system to control inflammation.
  • Exosomes play significant roles in ERK1/2 and autophagy activation, T. marneffei replication, and cytokine production during infection.