Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mitochondria01:37

Mitochondria

13.9K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
13.9K
Genomics02:02

Genomics

36.5K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
36.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Killiverse: an interactive multi-omics web resource for killifish.

bioRxiv : the preprint server for biology·2026
Same author

The problem with one-size-fits-all medicine: Biological sex and the aging immune system.

PLoS biology·2026
Same author

A multi-omic atlas in the African turquoise killifish reveals increased glucocorticoid signaling as a hallmark of brain aging.

bioRxiv : the preprint server for biology·2026
Same author

A dual role for cGAS in shaping cellular and organismal responses to genomic instability.

Genes & development·2026
Same author

Multi-tissue transcriptomic aging atlas reveals predictive aging biomarkers in the killifish.

Nature aging·2026
Same author

Estropausal gut microbiota transplant improves measures of ovarian function in adult mice.

Nature aging·2026

Related Experiment Video

Updated: Jul 25, 2025

Cell-Specific Paired Interrogation of the Mouse Ovarian Epigenome and Transcriptome
12:25

Cell-Specific Paired Interrogation of the Mouse Ovarian Epigenome and Transcriptome

Published on: February 24, 2023

899

Considerations for reproducible omics in aging research.

Param Priya Singh1,2, Bérénice A Benayoun3,4,5,6,7

  • 1Department of Anatomy, University of California, San Francisco, San Francisco, CA, USA. param.singh@ucsf.edu.

Nature Aging
|June 29, 2023
PubMed
Summary

High-throughput omics profiling reveals molecular aging mechanisms. This perspective offers best practices for designing and analyzing omics experiments in aging research for robust and reproducible results.

More Related Videos

Author Spotlight: Automated Lifespan Monitoring – Discovering Aging Dynamics with the Lifespan Machine
08:53

Author Spotlight: Automated Lifespan Monitoring – Discovering Aging Dynamics with the Lifespan Machine

Published on: January 26, 2024

1.1K
Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches
09:47

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches

Published on: December 15, 2023

1.1K

Related Experiment Videos

Last Updated: Jul 25, 2025

Cell-Specific Paired Interrogation of the Mouse Ovarian Epigenome and Transcriptome
12:25

Cell-Specific Paired Interrogation of the Mouse Ovarian Epigenome and Transcriptome

Published on: February 24, 2023

899
Author Spotlight: Automated Lifespan Monitoring – Discovering Aging Dynamics with the Lifespan Machine
08:53

Author Spotlight: Automated Lifespan Monitoring – Discovering Aging Dynamics with the Lifespan Machine

Published on: January 26, 2024

1.1K
Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches
09:47

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches

Published on: December 15, 2023

1.1K

Area of Science:

  • Molecular biology
  • Aging research
  • Bioinformatics

Background:

  • Technological advances enable comprehensive molecular profiling (transcriptomes, epigenomes, metabolomes, proteomes).
  • Profiling molecular landscapes in aging can uncover mechanisms of decline and disease.
  • High-throughput omics experiments present analytical and design challenges for reproducibility.

Purpose of the Study:

  • Provide guidelines for designing and analyzing omics experiments in aging research.
  • Address challenges in robustness and reproducibility of high-throughput omics data.
  • Offer considerations for long-term validation of omics studies in aging.

Main Methods:

  • Review of best practices in experimental design for omics studies.
  • Guidelines for data analysis in aging research using omics data.
  • Strategies for minimizing spurious variation and accounting for biological/technical parameters.

Main Results:

  • Identification of key considerations for robust omics experimental design.
  • Recommendations for rigorous data analysis to ensure reproducibility.
  • Emphasis on validation strategies for omics findings in aging.

Conclusions:

  • Effective design and analysis are crucial for reliable omics research in aging.
  • Adherence to best practices enhances the validity of molecular insights into aging.
  • Standardized approaches are needed for reproducible and impactful aging research.