Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Hydrolysis

Hydrolysis

Overview
Hydrolysis is a chemical reaction in which the addition of water breaks down a polymer into its simpler monomer units. For example, peptides break into amino acids, carbohydrates into simple sugars, and DNA into nucleotides. Enzymes often facilitate these processes.
Hydrolysis Reverses Dehydration Synthesis
Complex carbohydrates can be broken down by breaking the bonds between individual sugar units. The reaction breaks a glycosidic bond as water is added to the compound. The...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Integrated Genomic, Transcriptomic, and Circulating Biomarkers Predict Benefit to Immune Checkpoint Inhibitor Plus Chemotherapy in Advanced Non-Small Cell Lung Cancer.

MedComm·2026

Same author

Interfacial Nucleation Pathways Governing Polymorph Selection Revealed by Synchrotron-Based <i>In Situ</i> GIWAXS and Molecular Simulations.

Journal of the American Chemical Society·2026

Same author

Inorganic Ionic Polymerization-Anchored Polymer Networks for Ultrastrong and Ultratough Eutectogels.

Advanced materials (Deerfield Beach, Fla.)·2026

Same author

Controlled-release herbicide spheres: co-crystallization of 2,4-dichlorophenoxyacetic acid with l-menthol via green oiling-out process for low leaching and high activity.

Pest management science·2026

Same author

High-aspect-ratio plasmonic lithography via decaying feature amplification.

Optics express·2026

Same author

Chiral Manganese Halide Co-Crystals: A New Avenue for Efficient Circularly Polarized Luminescence.

Advanced materials (Deerfield Beach, Fla.)·2026

Search research articles

Related Experiment Video

Updated: Jul 24, 2025

High-Resolution Neutron Spectroscopy to Study Picosecond-Nanosecond Dynamics of Proteins and Hydration Water

High-Resolution Neutron Spectroscopy to Study Picosecond-Nanosecond Dynamics of Proteins and Hydration Water

Published on: April 28, 2022

Systematic study on lysozyme-hyaluronan complexes: Multi-spectroscopic characterization and molecular dynamics

Maolin Li¹, Xin Zhang¹, Dandan Han²

¹State Key Laboratory of Chemical Engineering, Tianjin University, Tianjin 300072, PR China.

International Journal of Biological Macromolecules

|July 2, 2023

Summary

Electrostatic interactions drive lysozyme (LYS) and hyaluronan (HA) complex formation, altering LYS structure. These biocompatible LYS-HA complexes show potential for drug delivery and food applications.

Keywords:

Complexes Hyaluronan Lysozyme Molecular dynamics simulation Multi-spectroscopy characterization

More Related Videos

Incorporating Target Protein Structure Flexibility and Dynamics in Computational Drug Discovery Using Ensemble-Based Docking Analysis

Incorporating Target Protein Structure Flexibility and Dynamics in Computational Drug Discovery Using Ensemble-Based Docking Analysis

Published on: June 20, 2025

Au-Interaction of Slp1 Polymers and Monolayer from Lysinibacillus sphaericus JG-B53 - QCM-D, ICP-MS and AFM as Tools for Biomolecule-metal Studies

Au-Interaction of Slp1 Polymers and Monolayer from Lysinibacillus sphaericus JG-B53 - QCM-D, ICP-MS and AFM as Tools for Biomolecule-metal Studies

Published on: January 19, 2016

Related Experiment Videos

Last Updated: Jul 24, 2025

High-Resolution Neutron Spectroscopy to Study Picosecond-Nanosecond Dynamics of Proteins and Hydration Water

High-Resolution Neutron Spectroscopy to Study Picosecond-Nanosecond Dynamics of Proteins and Hydration Water

Published on: April 28, 2022

Incorporating Target Protein Structure Flexibility and Dynamics in Computational Drug Discovery Using Ensemble-Based Docking Analysis

Incorporating Target Protein Structure Flexibility and Dynamics in Computational Drug Discovery Using Ensemble-Based Docking Analysis

Published on: June 20, 2025

Au-Interaction of Slp1 Polymers and Monolayer from Lysinibacillus sphaericus JG-B53 - QCM-D, ICP-MS and AFM as Tools for Biomolecule-metal Studies

Au-Interaction of Slp1 Polymers and Monolayer from Lysinibacillus sphaericus JG-B53 - QCM-D, ICP-MS and AFM as Tools for Biomolecule-metal Studies

Published on: January 19, 2016

Area of Science:

Biochemistry
Materials Science
Biophysics

Background:

Lysozyme (LYS) and hyaluronan (HA) are biopolymers with potential synergistic applications.
Understanding their complexation is crucial for developing novel biomaterials.

Purpose of the Study:

To elucidate the complexation mechanism between LYS and HA.
To investigate the driving forces and structural changes during LYS-HA complex formation.
To assess the biocompatibility and potential applications of LYS-HA complexes.

Main Methods:

Multi-spectroscopy techniques (Circular Dichroism, Fluorescence Spectroscopy).
Molecular Dynamics (MD) simulations.
Cell culture experiments (HT-29, HCT-116).

Main Results:

Electrostatic interactions are the primary driving force for LYS-HA self-assembly.
LYS-HA complexation alters the secondary structure of LYS (α-helix and β-sheet content).
MD simulations identified key interacting residues (ARG114 in LYS, 4ZB4 in HA).
LYS-HA complexes exhibit excellent biocompatibility.
Potential for encapsulating insoluble drugs and bioactives.

Conclusions:

LYS-HA complex formation is primarily driven by electrostatic forces, leading to structural modifications in LYS.
The study provides fundamental insights into LYS-HA interactions.
LYS-HA complexes are promising for applications in drug delivery, emulsion stabilization, and as foaming agents in the food industry.