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Synthetic Biology

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Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
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Microbial communities are dynamic environments where cell lysis releases free DNA into the surroundings. Other cells can take up this extracellular DNA through a process known as transformation.When a cell incorporates this foreign DNA into its genome, resulting in genetic modification, the process is known as transformation. Cells capable of this process are termed competent. Competence can be natural, as observed in certain bacteria and archaea, or artificially induced in the...
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Chromatin modification alters gene expression; therefore, scientists can add histone-modifying enzymes, histone variants, and chromatin remodeling complexes to somatic cells to aid reprogramming into pluripotent stem (iPS) cells.
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Using Synthetic Biology to Engineer Living Cells That Interface with Programmable Materials
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Synthetic epigenetics-assisted microbial chassis engineering.

Irene Komera1, Cong Gao1, Xiulai Chen1

  • 1State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, China; International Joint Laboratory on Food Safety, Jiangnan University, Wuxi 214122, China.

Trends in Microbiology
|July 3, 2023
PubMed
Summary
This summary is machine-generated.

Synthetic epigenetics offers solutions for microbial chassis engineering challenges. This approach addresses limitations in regulatory tool orthogonality, host metabolic fitness, and cell population heterogeneity for improved biotechnology.

Keywords:
epigeneticsgenetic circuitsgenetic engineeringmicrobial chassis engineering

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Area of Science:

  • Synthetic biology
  • Metabolic engineering
  • Epigenetics

Background:

  • Microbial chassis engineering is crucial for advancing biotechnological applications.
  • Current engineering approaches face limitations including regulatory tool orthogonality, host metabolic fitness, and cell population heterogeneity.

Purpose of the Study:

  • To explore the potential of synthetic epigenetics in overcoming key limitations in microbial chassis engineering.
  • To provide insights into the future prospects of synthetic epigenetics in biotechnology.

Main Methods:

  • Review and analysis of existing literature on microbial chassis engineering and synthetic epigenetics.
  • Conceptual exploration of how epigenetic modifications can be synthetically controlled within microbial hosts.

Main Results:

  • Synthetic epigenetics presents a promising strategy to enhance regulatory tool orthogonality by decoupling genetic and epigenetic layers.
  • It offers potential mechanisms to improve host metabolic fitness through dynamic epigenetic regulation.
  • Synthetic epigenetics can help mitigate cell population heterogeneity by establishing more stable and predictable cellular states.

Conclusions:

  • Synthetic epigenetics holds significant potential to revolutionize microbial chassis engineering.
  • Further research and development in this area could unlock more robust and efficient biotechnological platforms.