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Severe Refractory Hypocalcemia Caused by Denosumab
Sriharsha Dadana1, Sai Gundepalli1, Anusha Kondapalli1
1Internal Medicine, Cheyenne Regional Medical Center, Cheyenne, USA.
Denosumab, a treatment for bone metastases, can cause severe hypocalcemia. This case highlights a patient with breast cancer experiencing this rare but serious adverse effect.
Area of Science:
- Oncology
- Pharmacology
- Endocrinology
Background:
- Denosumab is a monoclonal antibody targeting RANKL, crucial for inhibiting bone resorption.
- It effectively reduces skeletal-related events in cancer patients with bone metastases.
- Severe hypocalcemia is a rare but critical adverse effect of denosumab therapy.
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