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Treatment of Angiosarcoma of the Head and Neck: A Systematic Review
Jessica E Houpe1, Edward W Seger1, Brett C Neill1
1Dr. Houpe is from the University of Kansas School of Medicine, Kansas City. Drs. Seger, Neill, and Hocker are from the Division of Dermatology, University of Kansas Medical Center, Kansas City. Drs. Kang and Alam are from the Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois. Dr. Alam also is from the Departments of Otolaryngology and Surgery. Dr. Tolkachjov is from Epiphany Dermatology, Lewisville, Texas; the Department of Dermatology, University of Texas at Southwestern, Dallas; Baylor University Medical Center, Dallas; and the Texas A&M College of Medicine, Dallas.
Abstract:
Primary cutaneous angiosarcoma (cAS) of the head and neck is a rare sarcoma with a poor prognosis and limited treatment options. We conducted a systematic review of treatments used for head and neck cAS and determined the treatment modalities that offer the longest mean overall survival (OS). Forty publications totaling 1295 patients were included. Both surgical and nonsurgical modalities have shown potential efficacy in the treatment of cAS; however, limited data preclude definitive recommendations. Multidisciplinary management of cAS should be considered to tailor treatment on a case-by-case basis.
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