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Drug Therapy01:28

Drug Therapy

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The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
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Psychosis: Goals of Pharmacotherapy01:26

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Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
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Psychosis and Antipsychotic Drugs: Overview01:28

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The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
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Insulin Formulations: Types and Delivery01:27

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Insulin preparations are categorized by their duration of action into short-acting and long-acting types. Two strategies are used to modify insulin's absorption and pharmacokinetic profile: slowing the absorption post-subcutaneous injection, or altering human insulin's amino acid sequence or protein structure. These changes retain the insulin's ability to bind to the insulin receptor, but alter its behavior in solution or after injection.
Short-acting insulins are divided into...
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Insulin: Dosing Regimen and Adverse Effects01:16

Insulin: Dosing Regimen and Adverse Effects

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Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
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Antidepressant Drugs: MAOIs and Other Agents01:23

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Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
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Text Message Reminders for Long-Acting Injectable Antipsychotics in Patients with Schizophrenia Spectrum Disorders.

Christina J Chen1, Wanda Hilliard2

  • 1Christina J. Chen, DNP, APRN, PMHNP-BC, School of Nursing, Texas Tech University Health Sciences Center, Lubbock, TX, USA.

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|July 6, 2023
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Summary
This summary is machine-generated.

Text message reminders significantly improved medication adherence for patients with schizophrenia spectrum disorders on long-acting injectable antipsychotics. This intervention increased compliance rates and reduced variability in medication timing.

Keywords:
community mental healthmedication adherencequality improvementschizophrenia

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Area of Science:

  • Psychiatry
  • Mental Health Technology
  • Pharmacological Adherence

Background:

  • Schizophrenia spectrum disorders present chronic management challenges.
  • Medication nonadherence in these patients elevates relapse and rehospitalization risks.
  • Long-acting injectable (LAI) antipsychotics enhance medication adherence compared to oral formulations.

Purpose of the Study:

  • To evaluate the efficacy of text message reminders in improving medication adherence for LAI antipsychotic administration.
  • To assess the impact of text reminders on compliance percentage and target day variability.

Main Methods:

  • A pre- and post-intervention study was conducted in a west Texas community mental health clinic.
  • Text message reminders were delivered 3 weeks, 3 days, and 3 hours before scheduled LAI administration.
  • The study included 49 patients diagnosed with schizophrenia spectrum disorders, measuring compliance and target day variability.

Main Results:

  • Pre-intervention compliance was 84.39% with a 3.55-day variability.
  • Post-intervention, compliance significantly increased to 91.24% (p = .014).
  • Target day variability significantly decreased to 1.33 days (p < .05).

Conclusions:

  • Text message reminders represent a potentially effective intervention for enhancing LAI antipsychotic adherence.
  • This method can improve medication compliance and reduce timing variability in patients with schizophrenia spectrum disorders.