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Smart G-quadruplex hydrogels: From preparations to comprehensive applications.

Jun Fang¹, Lijuan Zheng¹, Yan Liu¹

¹College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha 410128, China.

International Journal of Biological Macromolecules

|July 6, 2023

Summary

G-quadruplex hydrogels combine G-quadruplexes and hydrogels for advanced biomaterials. This review classifies their preparation and applications in medicine, biocatalysis, and biosensing.

Keywords:

Applications G-quadruplex hydrogels Preparations

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Area of Science:

Biomaterials Science
Supramolecular Chemistry

Background:

G-quadruplexes offer biocompatibility and unique biological functions.
Hydrogels provide hydrophilicity, water retention, and biodegradability.
Combining these creates intelligent G-quadruplex hydrogels.

Purpose of the Study:

To systematically classify G-quadruplex hydrogels based on preparation strategies and applications.
To elucidate how these hydrogels leverage the properties of both components.
To explore their utility in diverse scientific fields.

Main Methods:

Comprehensive literature review and classification.
Analysis of preparation methodologies.
Categorization of applications.

Main Results:

G-quadruplex hydrogels integrate G-quadruplex functions with hydrogel structures.
Applications span biomedicine, biocatalysis, biosensing, and biomaterials.
Key preparation strategies and functional mechanisms are detailed.

Conclusions:

G-quadruplex hydrogels represent a versatile class of intelligent biomaterials.
Further research is needed to address challenges in preparation, stability, and safety.
Future directions include optimizing their design for enhanced performance and broader applications.