Autonomic Dysfunction Related to Postacute SARS-CoV-2 Syndrome.

Area of Science:

• Neurology
• Cardiology
• Pulmonology
• Psychiatry
• Gastroenterology

Background:

• Post-acute SARS-CoV-2 (PASC) is a complex condition characterized by persistent symptoms following COVID-19.
• PASC encompasses a wide range of impairments, including neurological, autonomic, pulmonary, cardiac, psychiatric, gastrointestinal, and functional deficits.
• Autonomic dysfunction is a significant component of PASC, manifesting with symptoms such as dizziness, tachycardia, and cognitive difficulties ('brain fog').

Purpose of the Study:

• To describe the multifaceted nature of post-acute SARS-CoV-2 (PASC).
• To highlight the common presentations of autonomic dysfunction within PASC.
• To emphasize the importance of a multidisciplinary approach in managing PASC.

Main Methods:

• Review of clinical presentations and established literature on PASC.
• Identification of key symptoms associated with PASC and its autonomic component.
• Discussion of management strategies for PASC.

Main Results:

• PASC symptoms persist beyond the acute phase of COVID-19, affecting multiple organ systems.
• Autonomic dysfunction in PASC includes symptoms like dizziness, tachycardia, sweating, headache, syncope, labile blood pressure, exercise intolerance, and 'brain fog'.
• A comprehensive, multidisciplinary team approach is crucial for managing PASC.

Conclusions:

• PASC is a multi-system syndrome with significant autonomic involvement.
• Effective management of PASC necessitates a coordinated, multidisciplinary strategy.
• Interventions for PASC include both nonpharmacologic and pharmacologic options tailored to the patient's needs.