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Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness
Published on: May 3, 2018
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Arterial Stiffness in Patients with Bipolar Disorder
Aslı Kazgan Kılıçaslan1, Burcu Sırlıer Emir2, Sevler Yildiz3
1Department of Psychiatry, University of Bozok, Yozgat, Turkey.
Summary
Patients with bipolar disorder (BD) show increased arterial stiffness, a potential cardiovascular disease (CVD) risk factor. Further research is needed to understand the role of medications and BD itself in arterial health.
Area of Science:
- Cardiology
- Psychiatry
- Vascular Biology
Background:
- Bipolar disorder (BD) is recognized as an inflammatory and metabolic condition.
- Both BD and its treatments may influence cardiovascular disease (CVD) risk.
- Arterial stiffness is a key indicator of vascular health and a predictor of CVD.
Purpose of the Study:
- To investigate arterial stiffness in patients with bipolar disorder (BD).
- To compare arterial stiffness parameters between BD patients and healthy controls.
- To explore correlations between medication dosage and arterial stiffness in BD patients.
Main Methods:
- Study included 39 patients with BD type I in remission and 39 healthy controls.
- Carotid and femoral artery intima-media thickness (IMT) and arterial thickness were measured using Doppler ultrasonography.
- Elastic modulus and compliance were calculated as measures of arterial stiffness.
Main Results:
- Carotid artery elastic modulus was significantly higher in BD patients compared to controls (p=0.015).
- While IMT was greater in BD patients, the difference was not statistically significant.
- Positive correlations were found between chlorpromazine and lithium equivalent doses and specific arterial stiffness parameters.
Conclusions:
- Arterial stiffness may be a relevant factor for CVD risk in BD patients.
- Further studies are required to differentiate between BD-specific effects and medication impacts on arterial health.
- The potential arterial protective effects of mood stabilizers warrant further investigation.
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