IGF-1 Therapy Improves Muscle Size and Function in Experimental Peripheral Arterial Disease

Area of Science:

• Vascular Biology
• Muscle Physiology
• Regenerative Medicine

Background:

• Peripheral arterial disease (PAD) prevalence is rising, with limited therapeutic advancements.
• Skeletal muscle health is crucial for quality of life and outcomes in PAD patients.

Purpose of the Study:

• To investigate the efficacy of insulin-like growth factor (IGF)-1 therapy on skeletal muscle in a rodent model of PAD.
• To assess the impact of IGF-1 on muscle size, strength, and limb hemodynamics.
• To explore potential sex-dependent differences in response to IGF-1 treatment for PAD.

Main Methods:

• A rodent model of peripheral arterial disease was utilized.
• The ischemic limb was treated with insulin-like growth factor (IGF)-1.
• Muscle size, muscle strength, and limb hemodynamics were measured and compared between treatment groups.

Main Results:

• IGF-1 treatment significantly increased muscle size and strength in the ischemic limb.
• IGF-1 therapy did not improve limb hemodynamics (blood flow).
• The therapeutic effect of IGF-1 was notably larger in female mice compared to male mice.

Conclusions:

• IGF-1 therapy can enhance skeletal muscle mass and function in PAD, independent of hemodynamic improvements.
• Sex-specific responses to IGF-1 treatment in PAD warrant further investigation.
• These findings suggest potential for targeted therapies in PAD, considering sex differences.