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Relationship between Euthyroidism and Muscle Mass and Strength: A Systematic Review
Francesca Greco1, Chantalle Moulton1, Cristina Antinozzi1
1Department of Human Movement Sciences and Health, University of Rome 'Foro Italico', Roma, Italy.
Even within normal ranges, thyroid hormone levels impact muscle mass and strength. Low free triiodothyronine and high free thyroxine may reduce muscle function, particularly in older men.
Area of Science:
- Endocrinology
- Muscle Physiology
- Gerontology
Background:
- Thyroid hormones are vital for skeletal muscle development, influencing muscle mass and strength.
- The relationship between thyroid hormones and muscle parameters in euthyroid individuals remains unclear.
- Muscle mass and strength are key indicators of age-related health decline.
Approach:
- Systematic review of 13 observational studies.
- Searched PubMed, Scopus, and Web of Science databases.
- Included 241,044 participants, analyzing thyroid stimulating hormone, free triiodothyronine, free thyroxine, and thyroid hormone ratios.
Key Points:
- Low normal free triiodothyronine levels may be associated with reduced muscle mass and strength.
- High normal free thyroxine levels might correlate with diminished muscle function.
- A lower thyroid hormone ratio could indicate poorer muscle performance.
Conclusions:
- Thyroid hormone levels within the normal physiological range can influence muscle mass and strength.
- These associations appear more pronounced in older males.
- Further research is needed to elucidate the precise mechanisms linking euthyroid thyroid function to muscle health.
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