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Updated: Jul 23, 2025

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
Published on: July 30, 2017
Pyrosulfite-Involved Synthesis of Sulfides by Palladium-Catalyzed Decarboxylative Couplings
Xiaokang Li1, Bei Wei1, Yanlong Gong1
1School of Pharmacy, Shanxi Medical University, Taiyuan, Shanxi 030001, China.
Abstract:
The decarboxylative coupling using carboxylic acid and potassium metabisulfite, promoted by a palladium catalyst, is reported for the generation of sulfides. The coupling is performed using the easily available carboxylic acid and environmentally friendly inorganic sulfides as a divalent inorganic sulfur source. Not only aromatic acids but also aliphatic carboxylic acids are workable during the couplings. The method is applicable and practical to a scope of 20 examples and drug molecules.
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