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Nifedipine-induced gingival hyperplasia.

A A Shaftic, L L Widdup, M A Abate

    Drug Intelligence & Clinical Pharmacy
    |July 1, 1986
    PubMed
    Summary
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    Gingival hyperplasia, an overgrowth of gum tissue, can be caused by medications like nifedipine. Discontinuing nifedipine or switching to verapamil may resolve this common dental issue.

    Area of Science:

    • Dentistry
    • Pharmacology
    • Oral Medicine

    Background:

    • Gingival hyperplasia, characterized by increased gingival connective tissue, is a known side effect of certain medications.
    • Phenytoin and cyclosporine are commonly associated with drug-induced gingival hyperplasia.
    • This condition necessitates understanding medication-induced oral health changes.

    Observation:

    • A case report details gingival hyperplasia in a patient using nifedipine, a calcium channel blocker.
    • While less common than with other drugs, nifedipine can induce gingival overgrowth.
    • This highlights the importance of monitoring oral health in patients on nifedipine.

    Findings:

    • Nifedipine, like phenytoin and cyclosporine, can cause gingival hyperplasia.
    • Discontinuation of nifedipine is recommended if hyperplasia develops.

    Related Experiment Videos

  • Verapamil may be a suitable alternative, potentially improving the condition.

    • Implications:

    • Patients prescribed nifedipine should be informed about the risk of gingival hyperplasia.
    • Good oral hygiene practices are crucial for mitigating this risk.
    • Healthcare providers should consider nifedipine as a potential cause and explore alternatives like verapamil if hyperplasia occurs.