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Quantification of Reactive Oxygen Species Using 2′,7′-Dichlorofluorescein Diacetate Probe and Flow-Cytometry in Müller Glial Cells
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Redox Status in Retinitis Pigmentosa
L Olivares-González1,2, S Velasco1,2, I Campillo1,2
1Pathophysiology and Therapies for Vision Disorders, Principe Felipe Research Center (CIPF), Valencia, Spain.
Advances in Experimental Medicine and Biology
|July 13, 2023
Summary
Retinitis pigmentosa (RP) involves progressive vision loss due to inherited retinal dystrophy. Oxidative stress significantly worsens RP progression, suggesting antioxidant therapies may slow disease advancement.
Area of Science:
- Ophthalmology
- Genetics
- Cell Biology
Background:
- Retinitis pigmentosa (RP) is a common inherited retinal dystrophy causing progressive vision loss.
- RP's progression is exacerbated by oxidative damage and immune cell-derived factors.
- The retina, particularly rods, is highly susceptible to oxidative stress and lipid peroxidation.
Approach:
- This review focuses on the critical role of oxidative stress in RP pathogenesis.
- It examines the relationship between oxidative damage and the acceleration of retinal degeneration in RP.
- Evidence linking altered antioxidant-oxidant balance in RP patients and models is discussed.
Key Points:
- The oxidative hypothesis suggests retinal hyperoxia and reactive species accumulation after rod death worsen RP.
- Oxidative damage affects lipids, proteins, and DNA, intensifying retinal degeneration.
- Therapeutic strategies targeting oxidative stress reduction are emerging as potential RP treatments.
Conclusions:
- Oxidative stress is a key factor influencing the progression of retinitis pigmentosa.
- Understanding the oxidative damage mechanisms in RP is crucial for developing effective treatments.
- Targeting oxidative stress offers a promising avenue for slowing vision loss in RP patients.
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