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DaxibotulinumtoxinA-lanm (Daxxify™): A Comprehensive Overview.
Nicole Salame1, Ariel E Eber2, Jeffrey Dover3
1Department of Dermatology, Emory University School of Medicine, Atlanta, GA, USA.
Skin Therapy Letter
|July 13, 2023
Summary
DaxibotulinumtoxinA (DAXI) offers a novel, longer-lasting alternative to traditional botulinum toxin A injections for dynamic facial lines. This new formulation provides sustained results for up to six months, enhancing patient satisfaction.
Area of Science:
- Neurology
- Dermatology
- Biochemistry
Background:
- Botulinum toxin A (BoNTA) is widely used for aesthetic treatments, but its temporary effects necessitate frequent re-injections every 3-4 months.
- A need exists for longer-lasting neurotoxins to improve patient satisfaction and reduce suboptimal correction periods.
Purpose of the Study:
- To introduce and evaluate daxibotulinumtoxinA for injection (DAXI), a novel, long-acting BoNTA formulation approved for moderate to severe glabellar lines.
Main Methods:
- DAXI is a new BoNTA formulation utilizing a 150-kDa BoNTA (RTT150) and a proprietary peptide excipient (RTP004) instead of human serum albumin.
- FDA approval in September 2022 marked the introduction of DAXI for aesthetic indications.
Main Results:
- DAXI demonstrated a median duration of effect of 6 months for glabellar lines.
- Results lasted up to 9 months in some patients, indicating prolonged effectiveness.
Conclusions:
- DAXI represents a novel, safe, and long-lasting BoNTA option.
- Its unique formulation and extended duration offer improved durability and patient satisfaction for aesthetic treatments.
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