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Cardiac output (CO), the amount of blood the heart pumps per minute, is a parameter in cardiovascular physiology determined by stroke volume and heart rate. Stroke volume, the amount of blood pushed from one of the ventricles per heartbeat, is influenced by preload, afterload, and contractility.
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Updated: Jul 23, 2025

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
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Decrease of thyroid function after ischemic stroke is related to stroke severity.

Evgeny Sidorov1,2, Aruna Paul3, Chao Xu4

  • 1Department of Neurology, University of Oklahoma Health Sciences Center, 920 Stanton L. Young Blvd #2040, Oklahoma City, OK, 73104, USA. evgeny-sidorov@ouhsc.edu.

Thyroid Research
|July 13, 2023
PubMed
Summary
This summary is machine-generated.

Thyroid hormone levels, including free triiodothyronine (fT3), transiently decrease after acute ischemic stroke (AIS). Higher stroke severity is linked to a greater fT3 reduction, suggesting thyroid function changes may impact recovery.

Keywords:
Acute ischemic strokeStroke severityThyroid hormonesThyroxinTriiodothyronine

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Area of Science:

  • Neurology
  • Endocrinology
  • Internal Medicine

Background:

  • Thyroid hormones are crucial for brain function.
  • Low triiodothyronine (fT3) levels post-acute ischemic stroke (AIS) correlate with poorer outcomes.
  • The longitudinal dynamics of thyroid function following AIS are not well understood.

Purpose of the Study:

  • To longitudinally assess thyroid hormone levels after ischemic stroke.
  • To investigate the relationship between stroke severity and thyroid function changes.

Main Methods:

  • Prospective study tracking thyroid stimulating hormone (TSH), fT3, and free thyroxin (fT4) levels.
  • Evaluations conducted in hyper-acute (within 24h), acute (3-5 days), and chronic (3-6 months) stages.
  • Mixed regression models used to analyze hormone dynamics and National Institute of Health Stroke Scale (NIHSS) correlations.

Main Results:

  • TSH levels showed a non-significant decrease across stages.
  • fT3 levels significantly decreased from hyper-acute to acute stages, then recovered by the chronic stage (p < 0.01).
  • fT4 levels decreased acutely and showed a non-significant increase in the chronic stage (p = 0.02).
  • Increased NIHSS score was associated with a significant decrease in fT3 from hyper-acute to acute stages (p < 0.01).

Conclusions:

  • Ischemic stroke is associated with a transient decrease in thyroid hormones, particularly fT3.
  • Stroke severity appears to influence these thyroid function changes.
  • Further research is warranted to explore thyroid function correction as a potential therapeutic strategy for improving stroke outcomes.