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Total Antioxidant Capacity: Biochemical Aspects and Clinical Significance.

Andrea Silvestrini1,2, Elisabetta Meucci1,2, Bianca Maria Ricerca2,3

  • 1Dipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.

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|July 14, 2023
PubMed
Summary

Oxidative stress (OS) impacts health, but assessing total antioxidant capacity (TAC) can help manage it. Understanding TAC methods and clinical context is key for personalized antioxidant therapy.

Keywords:
metabolic syndromeobesityoxidative stressredox balancetotal antioxidant capacity

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Area of Science:

  • Biochemistry
  • Pathophysiology
  • Clinical Medicine

Background:

  • Oxidative stress (OS) arises from an imbalance in antioxidant levels, causing molecular, tissue, and cellular damage.
  • Antioxidant compounds are crucial for modulating OS and maintaining redox balance.
  • Accurate assessment of total antioxidant capacity (TAC) is vital for understanding and managing OS-related conditions.

Purpose of the Study:

  • To review methods for assessing total antioxidant capacity (TAC) in biological systems.
  • To clarify terminology and pathophysiological roles related to TAC.
  • To explore the clinical relevance of TAC in conditions like metabolic syndrome and infertility.

Main Methods:

  • Literature review of established and emerging methods for TAC assessment.
  • Analysis of pathophysiological mechanisms linking OS to disease.
  • Case study review focusing on metabolic syndrome and infertility.

Main Results:

  • Various methods exist to measure TAC, each with specific applications and limitations.
  • Clinical context is essential for accurate interpretation of TAC values.
  • TAC evaluation shows potential prognostic value in monitoring antioxidant supplementation for OS-related diseases.

Conclusions:

  • Standardized TAC assessment methods are needed for reliable clinical interpretation.
  • TAC evaluation can guide personalized therapeutic strategies for OS-related conditions.
  • Further research into TAC's prognostic role may enhance patient management and treatment precision.