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Fiber-optic Implantation for Chronic Optogenetic Stimulation of Brain Tissue

Fiber-optic Implantation for Chronic Optogenetic Stimulation of Brain Tissue

Published on: October 29, 2012

Multifunctional Fiber-Based Optoacoustic Emitter as a Bidirectional Brain Interface.

Nan Zheng¹, Ying Jiang², Shan Jiang³

¹Division of Materials Science and Engineering, Boston University, Boston, MA, 02215, USA.

Advanced Healthcare Materials

|July 14, 2023

Summary

A new fiber-based optoacoustic emitter enables simultaneous neural stimulation and recording without viral transfection. This bidirectional brain interface offers new insights into neural circuits and ultrasound neurostimulation.

Keywords:

bidirectional neural interfaces multifunctional fibers neuromodulation optoacoustic

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Area of Science:

Neuroscience
Biomedical Engineering
Materials Science

Background:

Bidirectional brain interfaces are crucial for understanding neurological diseases and developing treatments.
Existing methods often require viral transfection or suffer from interference between stimulation and recording.

Purpose of the Study:

To develop a miniaturized, fiber-based optoacoustic emitter (mFOE) for simultaneous neural stimulation ("write") and electrophysiology recording ("read").
To demonstrate the efficacy and safety of the mFOE for in vivo neural circuit investigation.

Main Methods:

Fabrication of a miniaturized multifunctional fiber-based optoacoustic emitter (mFOE).
Validation of optoacoustic stimulation in cultured rat cortical neurons using calcium imaging.
In vivo testing in mouse hippocampus for simultaneous optoacoustic stimulation and electrophysiological recording, including chronic implantation up to 1 month.

Main Results:

The mFOE successfully achieved simultaneous optoacoustic stimulation and neural recording without viral transfection.
Demonstrated orthogonality between optoacoustic waves and electrical fields, preventing interference.
Confirmed successful in vivo application in mouse hippocampus with minimal observed brain tissue damage.

Conclusions:

The mFOE provides a novel, non-invasive bidirectional brain interface for neural circuit investigation.
This technology advances ultrasound neurostimulation and offers potential for neurological disease therapies.
The mFOE opens new avenues for fundamental neuroscience research and clinical applications.