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Isolated nonsyndromic cleft palate: multicenter epidemiological study in the Brazil
Samuel Trezena1, Renato Assis Machado2,3,4, Silvia Regina de Almeida Reis5
1Postgraduate Program in Primary Health Care, State University of Montes Claros, UNIMONTES, Prof. Darcy Ribeiro University Campus, Prof. Rui Braga Avenue, Vila Mauricéia, Montes Claros, MG, Postal Code: 39401-089, Brazil. samueltrezena@gmail.com.
BMC Oral Health
|July 14, 2023
Summary
Nonsyndromic cleft palate (NSCP) is more common in white females. Complete NSCP links to maternal health issues, medication use, and family history, increasing risks. This study highlights key epidemiological factors in Brazil.
Area of Science:
- Craniofacial development
- Congenital malformations
- Epidemiology
Background:
- Nonsyndromic orofacial clefts (NSOC) are common congenital malformations.
- Nonsyndromic cleft palate (NSCP) development may differ from other NSOC.
- Limited research focuses specifically on NSCP.
Purpose of the Study:
- To describe epidemiological findings of isolated nonsyndromic cleft palate (NSCP) patients in Brazil.
- To investigate sociodemographic and clinical characteristics of NSCP.
- To analyze pregnancy and family history in relation to NSCP.
Main Methods:
- Cross-sectional, multicenter study in three Brazilian states.
- Data collected from patient records (November 2021 - June 2022).
- Statistical analysis included Pearson's chi-square and ANOVA tests.
Main Results:
- The majority of patients were female (58.1%) and white (60.7%).
- Complete NSCP was associated with medical problems during pregnancy (p=0.016, OR=1.94).
- Medication use during pregnancy (OR=1.35) and family history (OR=1.44) increased the likelihood of complete NSCP.
Conclusions:
- NSCP is most prevalent in white females.
- Complete NSCP is linked to maternal health issues during pregnancy.
- Maternal medication use and family history are risk factors for complete NSCP.
