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Primary Lymphoid Organs

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...

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Updated: Jul 23, 2025

Application of Laparoscopic Partial Splenectomy with Total Blood Flow Occlusion in Benign Splenic Lesions

Application of Laparoscopic Partial Splenectomy with Total Blood Flow Occlusion in Benign Splenic Lesions

Published on: December 20, 2024

Primary Splenic Diffuse Large B-Cell Lymphoma: A Case Report.

Nuno Maia Neves¹, Ana Pestana Lopes², Susana Carvalho Coelho¹

¹Internal Medicine Department, Hospital da Luz Lisboa, Lisbon, Portugal.

European Journal of Case Reports in Internal Medicine

|July 17, 2023

Summary

This summary is machine-generated.

Primary splenic diffuse large B-cell lymphoma (PS-DLBCL) is a rare cause of splenomegaly. Splenic biopsy is crucial for diagnosing this challenging condition when other organs are not involved.

Keywords:

Primary splenic lymphoma diffuse large B-cell lymphoma non-Hodgkin lymphoma splenic nodules splenomegaly

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Area of Science:

Hematology
Oncology
Pathology

Background:

Primary splenic lymphoma (PSL) is an uncommon cause of splenomegaly or splenic nodules.
Splenic secondary involvement is more frequent than primary splenic lymphoma in lymphoproliferative disorders.

Purpose of the Study:

To highlight the broad differential diagnosis for splenomegaly and splenic nodules.
To emphasize the diagnostic utility of splenic biopsy.
To discuss primary splenic diffuse large B-cell lymphoma (PS-DLBCL), a rare entity.

Main Methods:

Case presentation of a 49-year-old woman with PS-DLBCL.
Ultrasound-guided splenic biopsy for definitive diagnosis.
Review of diagnostic challenges and literature.

Main Results:

The patient was diagnosed with PS-DLBCL, with no other organ involvement.
Splenic biopsy confirmed the diagnosis, underscoring its importance.

Conclusions:

The differential diagnosis of splenic lesions is extensive, including hematological, infectious, and non-malignant diseases.
PS-DLBCL is a rare condition, representing 1% of DLBCL cases.
Splenic biopsy is essential for diagnosing rare splenic pathologies like PS-DLBCL.