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Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
Published on: May 2, 2025
221
Epigenetic modification in diabetic kidney disease.
Zhe Liu1,2, Jiahui Liu1, Wanning Wang3
1Public Research Platform, First Hospital of Jilin University, Changchun, Jilin, China.
Frontiers in Endocrinology
|July 17, 2023
Summary
Epigenetic modifications influence diabetic kidney disease (DKD) development. Targeting these epigenetic changes offers potential for novel therapies and early diagnosis of DKD, a major diabetic complication.
Area of Science:
- Nephrology
- Endocrinology
- Epigenetics
Background:
- Diabetic kidney disease (DKD) is a leading cause of mortality in diabetic patients, characterized by proteinuria and reduced renal filtration.
- Current treatments for DKD offer only partial benefits and limited predictive power for disease progression.
- There is a critical need for novel therapeutic strategies and biomarkers for DKD management.
Purpose of the Study:
- To review the role of epigenetic modifications in the pathogenesis of diabetic kidney disease (DKD).
- To evaluate the potential of epigenetic therapies for treating DKD.
- To highlight the significance of epigenetic alterations as early diagnostic and therapeutic targets.
Main Methods:
- Literature review focusing on epigenetic mechanisms in DKD.
- Analysis of DNA methylation, histone modification, and noncoding RNA changes in DKD.
- Evaluation of existing and potential epigenetic therapeutic strategies.
Main Results:
- Epigenetic variations, including DNA methylation and histone modifications, are integral to DKD pathogenesis.
- These epigenetic changes are implicated in DKD-related inflammation, oxidative stress, and abnormal signaling pathways.
- DKD may be reversible at certain stages, underscoring the value of epigenetic targets.
Conclusions:
- Epigenetic modifications play a crucial role in the development and progression of diabetic kidney disease (DKD).
- Targeting epigenetic alterations presents a promising avenue for developing novel treatments and early diagnostic biomarkers for DKD.
- Further research into epigenetic mechanisms is essential for advancing DKD therapy and preventing end-stage renal disease.
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