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Updated: Jul 23, 2025

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Photocatalyzed Hydroaminodifluoroalkylation of Alkenes
Pierre Fossé1, Emmanuel Pfund1, Thierry Lequeux1
1Normandie Université, Laboratoire de Chimie Moléculaire et Thioorganique, LCMT UMR 6507 ENSICAEN, UNICAEN, CNRS, 6 Bd. du Maréchal Juin, 14050, Caen, France.
Abstract:
The synthesis of undescribed β-aminodifluoroethylsulfinates and their uses in the hydroaminodifluoroalkylation of alkenes is reported. This reaction is performed in the presence of a photocatalyst (4CzIPN, Ru complexes) and enables the direct incorporation of a β-difluoroamine moiety into vinylic aryls, unactivated alkenes, and electron-rich, or -deficient alkenes. The mechanism was studied, and the formation of a gem-difluoromethyl radical was observed after the selective oxidation of the sulfinate function.
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