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Published on: August 11, 2018
Dupilumab-Associated Sweet Syndrome
Edward Fernandez1, Wells Chandler1, Paul R Long1
1Drs. Fernandez and Fadugba are from the Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia. Drs. Chandler, Long, and Palmer are from Geisinger Medical Center, Danville, Pennsylvania. Dr. Chandler is from the Department of Laboratory Medicine, and Drs. Long and Palmer are from the Department of Dermatology.
Abstract:
Sweet syndrome (SS), also known as acute febrile neutrophilic dermatosis, is characterized by the abrupt appearance of edematous and erythematous papules, plaques, or nodules on the skin that have a distinct histopathologic appearance. Several subtypes of SS exist, including classic (also referred to as idiopathic) and drug induced. Although multiple medications have been implicated as causative agents, we present a rare case of SS caused by dupilumab, a monoclonal antibody therapy, used in the treatment of severe eosinophilic asthma and other conditions. Clinicians should be aware of this potential adverse reaction, as prompt recognition and treatment are essential.
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