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Anti-gout and Urate-lowering Potentials of Curcumin: A Review from Bench to Beside
Amir Masoud Jafari-Nozad1, Amirsajad Jafari2, Saman Yousefi3
1Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran.
Background:
Gouty arthritis is a complex form of inflammatory arthritis, triggered by the sedimentation of monosodium urate crystals in periarticular tissues, synovial joints, and other sites in the body. Curcumin is a natural polyphenol compound, isolated from the rhizome of the plant Curcuma longa, possessing countless physiological features, including antioxidant, anti-inflammatory, and anti-rheumatic qualities.
Objective:
This study aimed to discuss the beneficial impacts of curcumin and its mechanism in treating gout disease.
Methods:
Ten English and Persian databases were used to conduct a thorough literature search. Studies examining the anti-gouty arthritis effects of curcumin and meeting the inclusion criteria were included.
Results:
According to the studies, curcumin has shown xanthine oxidase and urate transporter- 1 inhibitory properties, uric acid inhibitory characteristics, and antioxidant and anti- inflammatory effects. However, some articles found no prominent reduction in uric acid levels.
Conclusion:
In this review, we emphasized the potency of curcumin and its compounds against gouty arthritis. Despite the potency, we suggest an additional well-designed evaluation of curcumin, before its therapeutic effectiveness is completely approved as an antigouty arthritis agent.
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