Fucoidan-coated coils improve healing in a rabbit elastase aneurysm model.

Area of Science:

• Biomedical Engineering
• Vascular Surgery
• Materials Science

Background:

• Aneurysm recanalization after coil embolization remains a clinical challenge.
• Optimizing aneurysm healing is crucial for successful endovascular treatment.
• Fucoidan-coated coils are proposed to enhance healing and limit recanalization.

Purpose of the Study:

• To evaluate the efficacy and safety of fucoidan-coated coils.
• To assess fibrosis and neointima formation using advanced imaging techniques.
• To compare fucoidan-coated coils with bare platinum and dextran-coated coils.

Main Methods:

• A feasibility study using rabbit elastase-induced aneurysms.
• Embolization with bare platinum, fucoidan-coated, or dextran-coated coils.
• Assessment via digital subtraction angiography, histology, and multiphoton microscopy at 1 month.

Main Results:

• A trend towards reduced recanalization was observed with fucoidan-coated coils.
• Significantly increased collagen in the aneurysm neck was noted in the fucoidan group compared to bare platinum coils (P=0.011).
• Improved histological healing scores and collagen organization were achieved with fucoidan-coated coils.

Conclusions:

• Fucoidan-coated coils are feasible and effective in improving aneurysm healing.
• This approach demonstrates potential for enhanced healing in endovascular aneurysm treatment.
• Further research is warranted to confirm long-term safety and efficacy.