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Risk Factors for Treatment Failure in Neonates With Skin and Soft Tissue Infection: A Retrospective Cohort Study
Purva Patel1, Catherine E Foster2, Grant Stimes2,3
1Divisions of Pediatric Hospital Medicine, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.
Clinical Pediatrics
|July 26, 2023
Summary
Treatment failure in neonates with skin and soft tissue infections (SSTIs) occurred in 8% of cases. Perirectal SSTIs were a significant risk factor for treatment failure in these young patients.
Area of Science:
- Neonatal Medicine
- Pediatric Infectious Diseases
- Dermatology
Background:
- Skin and soft tissue infections (SSTIs) are common in neonates.
- Understanding treatment failure is crucial for optimizing care.
- Risk factors for SSTI treatment failure in neonates require further investigation.
Purpose of the Study:
- To determine the frequency of treatment failure in neonates with SSTIs.
- To identify risk factors associated with treatment failure in this population.
- To inform clinical practice and future research directions.
Main Methods:
- Retrospective cohort study design.
- Inclusion of neonates aged 0-28 days with uncomplicated SSTIs.
- Data collection via chart review from a quaternary care children's hospital (2009-2017).
Main Results:
- Treatment failure observed in 8% (17/202) of neonates on oral antibiotics.
- Perirectal SSTIs were associated with increased odds of treatment failure (OR = 4.08).
- Methicillin-resistant Staphylococcus aureus and clindamycin use were noted in some failure cases.
Conclusions:
- Perirectal SSTIs represent a significant risk factor for treatment failure in neonates.
- Further research is needed to develop targeted prevention strategies for perirectal SSTIs.
- Optimizing antibiotic regimens and management for specific SSTI locations is warranted.
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