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Use of Granulocyte-Colony Stimulating Factor for Beta-Lactam Induced Neutropenia in Children With Bacterial
Cheng Yu Yen1, Sheldon L Kaplan2, Debra L Palazzi2
1Department of Pharmacy (CYY, GTS), Texas Children's Hospital, Houston, TX.
Insights
This case series explores granulocyte-colony stimulating factor (G-CSF) use for treating pediatric neutropenia caused by beta-lactam antibiotics. G-CSF offers a potential treatment option for this serious side effect in children.
Area of Science:
- Pediatric pharmacology
- Hematology
- Infectious diseases
Background:
- Drug-induced neutropenia is a rare but severe complication in children on prolonged beta-lactam antibiotics.
- Managing beta-lactam-induced neutropenia in pediatric patients is challenging, often necessitating treatment changes.
- Limited data exist on granulocyte-colony stimulating factor (G-CSF) efficacy for drug-induced neutropenia in children.
Purpose of the Study:
- To report the use of G-CSF in pediatric patients experiencing neutropenia due to beta-lactam antibiotic therapy.
- To evaluate G-CSF as a therapeutic option for beta-lactam-induced neutropenia in children with bacterial meningitis.
Main Methods:
- A case series design was employed.
- Four pediatric patients (3 months to 18 years) with bacterial meningitis and beta-lactam-induced neutropenia were treated with G-CSF.
- Clinical data on G-CSF administration and patient outcomes were collected.
Main Results:
- The study describes the application of G-CSF in four pediatric cases of beta-lactam-induced neutropenia.
- Outcomes related to G-CSF treatment for this specific condition in children are presented.
Conclusions:
- G-CSF may be a viable treatment option for beta-lactam-induced neutropenia in pediatric patients.
- Further research is warranted to establish the safety and efficacy of G-CSF in this pediatric population.
Abstract:
Drug induced neutropenia is an uncommon but potentially serious side effect in children receiving prolonged β-lactam antibiotic therapy. Management of β-lactam induced neutropenia in children remains challenging and often requires antibiotic therapy interruption or modification. There are limited data in pediatric patients about use of granulocyte-colony stimulating factor (G-CSF) for the treatment of drug induced neutropenia. We report the use of G-CSF for β-lactam induced neutropenia in four pediatric patients between the ages of 3 months and 18 years with bacterial meningitis in this case series.
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