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TP53BP2: Roles in suppressing tumorigenesis and therapeutic opportunities

Yunfei Huo1, Ke Cao1, Buxin Kou1

  • 1Beijing Institute of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.

Genes & Diseases
|July 26, 2023
PubMed

Insights

Apoptosis stimulating protein 2 of p53 (ASPP2) is crucial in tumor development and impacts patient survival. Targeting ASPP2 offers potential new strategies for treating malignant tumors.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cellular Biology

Background:

  • Malignant tumors pose a significant global health challenge.
  • Tumor suppressor p53-binding protein 2 (TP53BP2), also known as apoptosis stimulating protein 2 of p53 (ASPP2), is vital in tumorigenesis.
  • TP53BP2 expression correlates with patient prognosis and survival rates in malignant tumors.

Purpose of the Study:

  • To review the multifaceted role of TP53BP2 in tumor development.
  • To elucidate the signaling pathways regulated by TP53BP2.
  • To highlight TP53BP2 as a potential therapeutic target for cancer treatment.

Main Methods:

  • Literature review of studies on TP53BP2 function in tumorigenesis.
  • Analysis of TP53BP2 interactions with key proteins (e.g., p53, NF-κB p65, YAP).
  • Examination of TP53BP2's regulation of cellular processes (proliferation, apoptosis, migration, EMT, drug resistance) via signaling pathways.

Main Results:

  • TP53BP2 interacts with numerous proteins to modulate cellular functions.
  • TP53BP2 influences critical cancer hallmarks including proliferation, apoptosis, migration, EMT, and drug resistance.
  • TP53BP2 regulates downstream pathways such as NF-κB, RAS/MAPK, and PI3K/AKT.

Conclusions:

  • TP53BP2 plays a critical role in both p53-dependent and independent pathways during tumorigenesis.
  • Understanding TP53BP2's regulatory network provides insights into cancer progression.
  • TP53BP2 represents a promising therapeutic target for developing novel anti-cancer strategies.
Keywords:
Binding proteinsSignaling pathwaysTP53TP53BP2Tumor developmentTumorigenesis

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