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Unconventional Strategies for Solid Organ Transplantation and Special Transplantation Scenarios

Balasubramanya Rangaswamy1, Christopher B Hughes2, Biatta Sholosh3

  • 1Southwest Medical Imaging, 9700 North 91st Street, C-200, Scottzdale, AZ 85258, USA.

Radiologic Clinics of North America
|July 26, 2023
PubMed

Insights

Solid organ transplantation offers long-term solutions for end-organ failure. Innovative strategies like domino liver transplants and paired organ donation increase organ availability to meet recipient demand.

Area of Science:

  • Transplantation immunology and surgical innovation.

Background:

  • Solid organ transplantation is a vital treatment for end-organ failure.
  • Current donor pools (cadaveric and living) are insufficient to meet the high demand for transplants.

Purpose of the Study:

  • To explore innovative strategies for increasing organ availability in transplantation.
  • To address the gap between organ donor numbers and recipient needs.

Main Methods:

  • Review of advanced transplantation techniques.
  • Discussion of strategies including domino liver transplantation, paired organ donation, and ABO incompatible transplants.
  • Consideration of surgically complex procedures like split liver transplantation and ex vivo liver resection with auto-transplantation.

Main Results:

  • Several innovative strategies can augment the supply of transplantable organs.
  • Techniques such as domino liver transplantation, paired organ donation, and ABO incompatible transplants enhance organ availability.
  • Complex procedures are feasible at specialized transplant centers.

Conclusions:

  • Innovative approaches are crucial to expand organ availability for transplantation.
  • Addressing donor shortages requires multifaceted strategies, including advanced surgical techniques and alternative donation models.
  • Tertiary transplant centers are advancing the feasibility of complex organ transplant procedures.
Keywords:
ABO incompatible TransplantDomino transplantEx vivo liver resection and auto transplantationPaired organ donationSplit liver transplant

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