Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Electroconvulsive Therapy01:30

Electroconvulsive Therapy

69
Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early...
69
Long-term Depression01:03

Long-term Depression

2.6K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
2.6K
Antidepressant Drugs: Overview01:25

Antidepressant Drugs: Overview

579
Antidepressant drugs are a class of medications primarily used for treating various mood disorders, including major depression, anxiety disorders, and other related conditions. These medicines work by modulating the neurotransmitter balance within the brain, alleviating depressive symptoms. Antidepressants can be broadly categorized into several groups according to their mechanism of action and chemical structure: Selective Serotonin Reuptake Inhibitors (SSRIs), Serotonin-Norepinephrine...
579
Antiepileptic Drugs: Potassium Channel Activators01:20

Antiepileptic Drugs: Potassium Channel Activators

214
Ezocgabine or retigabine, an antiepileptic drug of remarkable efficacy, has revolutionized the management of seizures. It is a potassium channel activator, explicitly targeting the family of Q subtype potassium channels. It enhances the transmembrane potassium currents, regulating neuronal excitability. This action stabilizes the resting membrane potential, a pivotal factor in mitigating the hyperexcitability that characterizes epilepsy.
Ezogabine has gained approval as an adjunctive treatment...
214

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Psychological autopsy study of suicide risk factors in the Colombian Coffee Region, 2017-2019.

Colombia medica (Cali, Colombia)·2025
Same author

Validation of the Colombian-Spanish Suicidality Scale for Screening Suicide Risk in Clinical and Community Settings.

Journal of clinical medicine·2025
Same author

Assessment of Cognitive Performance in Bipolar Disorder Type I Patients and Their Unaffected Offspring.

Revista Colombiana de psiquiatria (English ed.)·2024
Same author

Geospatial investigations in Colombia reveal variations in the distribution of mood and psychotic disorders.

Communications medicine·2024
Same author

Electroconvulsive Therapy Impact on Memory Performance in Patients With Depression.

Revista Colombiana de psiquiatria (English ed.)·2021
Same author

Neuropsychiatric symptoms as the only acute manifestation of a stroke in the left hemisphere. Case report.

Revista Colombiana de psiquiatria (English ed.)·2020

Related Experiment Video

Updated: Jul 21, 2025

Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins
09:07

Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins

Published on: August 15, 2017

12.1K

Electroconvulsive Therapy Impact on Memory Performance in Patients With Depression.

Oscar Mauricio Castaño Ramírez1, Carlos Andrés Gómez Bedoya1, Rocío Lemos Buitrago1

  • 1Department of Mental Health and Human Behavior, University of Caldas, Manizales, Colombia.

Revista Colombiana De Psiquiatria (English Ed.)
|July 27, 2023
PubMed
Summary

Electroconvulsive therapy significantly improved depression symptoms without negatively impacting most memory functions. Delayed recognition memory showed minor effects, particularly in patients with lower education and bitemporal electrode placement.

Keywords:
DepresiónElectroconvulsive therapy (ECT)MemoriaMemoryNeuropsychological testing DepressionPruebas neuropsicológicasTerapia electroconvulsiva (TEC)

More Related Videos

Pupillary Response as Assessment of Effective Seizure Induction by Electroconvulsive Therapy
04:51

Pupillary Response as Assessment of Effective Seizure Induction by Electroconvulsive Therapy

Published on: April 11, 2019

9.4K
Transcranial Direct Current Stimulation tDCS for Memory Enhancement
10:37

Transcranial Direct Current Stimulation tDCS for Memory Enhancement

Published on: September 18, 2021

14.1K

Related Experiment Videos

Last Updated: Jul 21, 2025

Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins
09:07

Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins

Published on: August 15, 2017

12.1K
Pupillary Response as Assessment of Effective Seizure Induction by Electroconvulsive Therapy
04:51

Pupillary Response as Assessment of Effective Seizure Induction by Electroconvulsive Therapy

Published on: April 11, 2019

9.4K
Transcranial Direct Current Stimulation tDCS for Memory Enhancement
10:37

Transcranial Direct Current Stimulation tDCS for Memory Enhancement

Published on: September 18, 2021

14.1K

Area of Science:

  • Neuroscience
  • Psychiatry
  • Cognitive Psychology

Background:

  • Electroconvulsive therapy (ECT) safety has improved, with cognitive effects, particularly memory, being a primary concern.
  • Negative public and professional perceptions of ECT persist in Colombia, potentially hindering its use.
  • This study addresses the need for more data on ECT's cognitive impact in severe depression.

Purpose of the Study:

  • To evaluate changes in memory and depressive symptom severity before and after ECT in Colombian patients.
  • To provide evidence that may help re-evaluate public and professional opinions on ECT.

Main Methods:

  • Twenty-three patients with severe depression (ages 23-70) underwent ECT.
  • Depressive symptoms were assessed using the Hamilton Depression Scale (HAMD).
  • Memory was evaluated using the Rey Auditory Verbal Learning Test (RAVLT) pre-ECT and post-ECT.

Main Results:

  • ECT significantly reduced depression ratings.
  • No significant changes were observed in RAVLT learning trials or delayed recall.
  • A significant decrease in delayed recognition performance was noted post-ECT.

Conclusions:

  • Cognitive assessment before and after ECT is a practical and valuable procedure.
  • ECT does not generally impair memory function in patients with depression.
  • Delayed recognition memory may be affected by ECT, especially in individuals with lower education or bitemporal electrode placement.