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Recent Advances in the DNA-Mediated Multi-Mode Analytical Methods for Biological Samples.
1School of Chemistry, Sun Yat-sen University, Guangzhou 510006, China.
Biosensors
|July 28, 2023
Summary
DNA nanotechnology enables advanced biosensing by combining multiple detection methods. This review covers DNA-mediated multi-mode probes and their applications in complex biological analysis.
Area of Science:
- Biotechnology
- Nanotechnology
- Analytical Chemistry
Background:
- DNA nanotechnology offers precise programmability, synthesis ease, and stability for biosensing.
- Multi-mode analytical methods enhance sensitivity, accuracy, and throughput by integrating detection techniques.
- Combining DNA nanotechnology with multi-mode analysis improves selectivity and efficiency for biological samples.
Purpose of the Study:
- To review recent progress in DNA-mediated multi-mode probe preparation.
- To summarize advances in DNA-mediated multi-mode analytical methods for biological samples.
- To introduce current applications in biomarker analysis, bioimaging, and biological monitoring.
Main Methods:
- Review of deoxyribozyme, aptamer, templated-DNA, and G-quadruplex-mediated probe strategies.
- Detailed summary of DNA-mediated multi-mode analytical methods.
- Introduction to applications in biomarker, bioimaging, and biological monitoring analyses.
Main Results:
- Progress in preparing various DNA-mediated multi-mode probes is detailed.
- Advances in applying these methods to biological samples are summarized.
- Current applications demonstrate effectiveness in biomarker analysis, bioimaging, and monitoring.
Conclusions:
- DNA-mediated multi-mode analytical methods significantly enhance biosensing capabilities.
- These integrated approaches offer improved selectivity, sensitivity, accuracy, and throughput.
- Future trends point towards broader applications in complex biological analysis.
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