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Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles

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Rapid Detection of Microparticles Using a Microfluidic Resistive Pulse Sensor Based on Bipolar Pulse-Width

Ruiting Xu¹, Leixin Ouyang¹, Rubia Shaik²

¹Department of Mechanical Engineering, University of Akron, Akron, OH 44325, USA.

|July 28, 2023

Summary

This study introduces a novel resistive pulse sensor for high-throughput analysis of microparticles. The multiplexing sensor achieves accurate particle sizing and counting, advancing micro/nano bio-object analysis.

Keywords:

bipolar pulse high throughput iterative cancellation microfluidics particle counting resistive pulse sensor signal multiplexing

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Area of Science:

Biomedical Engineering
Analytical Chemistry
Nanotechnology

Background:

Resistive pulse sensing offers multi-parametric analysis of micro/nano bio-objects.
Traditional methods suffer from low throughput, limiting clinical diagnostics and drug discovery applications.

Purpose of the Study:

To develop a high-throughput resistive pulse sensor for microparticle analysis.
To overcome the throughput limitations of conventional resistive pulse sensors.

Main Methods:

A bipolar pulse-width, multiplexing-based resistive pulse sensor design was implemented.
Signal multiplexing was achieved using strategically placed electrodes within parallel sensing channels.
A correlation analysis and iterative cancellation scheme were used for signal demodulation.

Main Results:

The sensor demonstrated high-throughput analysis capabilities for microparticles.
Accurate particle sizing (2.6% error) and counting (6.1% error) were validated using microparticle mixtures.
The sensor's efficacy was further confirmed through analysis of HeLa cells.

Conclusions:

The developed sensor enables high-throughput, accurate analysis of micro/nano bio-objects.
This technology has significant potential for applications in clinical diagnostics and drug discovery.
The multiplexing strategy offers a promising approach for enhancing sensor performance.