Hypervalent Iodine Mediated Synthesis of Sulfinamidines from Sulfenamides
Guoling Huang1, Jianlin Ye1, Muhammad Adnan Bashir2
1Laboratory of Marine Green Fine Chemicals, School of Chemistry and Chemical Engineering, Lingnan Normal University, Zhanjiang, 524048, P. R. China.
Abstract:
In this study, we present a novel, efficient method for the oxidative amination of sulfenamides using diacetoxyiodobenzene (PhI(OAc)2) and amines under basic conditions. This innovative technique streamlines the synthesis of sulfinamidines under mild, metal-free conditions, achieving outstanding yields of up to 99%. Furthermore, we propose possible pathways that elucidate the observed molecular sequence of events in this reaction. This cutting-edge approach not only advances the synthesis of valuable sulfinamidine compounds but also expands the synthetic toolbox available to chemists, paving the way for future discoveries in organic synthesis and potential applications in medicinal chemistry.
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