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Cell Surface Vibrations Distinguish Malignant from Benign Cells.

Ishay Wohl1, Julia Sajman1, Eilon Sherman1

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Cell membrane vibrations and mechanical work dissipation are reduced in T cells when calcium channels are blocked. Malignant cells exhibit higher vibrations than benign cells, suggesting a potential diagnostic marker.

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Area of Science:

  • Cellular mechanics
  • Biophysics
  • Cancer biology

Background:

  • Cell mechanical properties are vital for physiological and pathological processes.
  • The relationship between cell state, rigidity, and surface vibrations is not well understood.

Purpose of the Study:

  • To investigate the relationship between cell mechanical properties and surface vibrations.
  • To explore the potential of cell vibrations as a biomarker for malignancy.

Main Methods:

  • Atomic Force Microscopy (AFM) measurements on T cells.
  • TIRF microscopy and dynamic laser speckle measurements on cancer cell lines.
  • Pharmacological manipulation of T-type Ca++-channels.

Main Results:

  • A negative correlation was observed between cell surface stiffness and vibrations in T cells.
  • Blocking T-type Ca++-channels reduced actin tension and increased membrane vibrations.
  • Malignant cell lines showed significantly higher membrane vibrations compared to benign cells.

Conclusions:

  • Cell membrane vibrations and mechanical work dissipation are elevated in malignant cells.
  • These mechanical properties may serve as indicators for detecting and monitoring cancer.